IduniX
One honest map of the Nabus longevity reference network — hallmark, mechanism, site, and what the evidence actually is. Network-wide, no human lifespan RCT.
What this is
IduniX is the entry point to a network of independent mechanism reference sites, one per aging pathway. It does one job: map the hallmarks of aging to the sites that cover them, state the shared evidence standard once, and link out. It publishes no dose, no protocol, and no intervention claim of its own — it is a map, not a plan. It is not a stack, not a regimen, and it never tells you to combine sites.
The 12 hallmarks of aging, mapped
Descriptive, not prescriptive. Four hallmarks currently have a live, source-verified mechanism site; the rest have none yet. No mapping is invented for a site that does not exist. Full detail on the hallmarks page.
| # | Hallmark of aging | Mechanism site |
|---|---|---|
| 1 | Genomic instability Accumulating DNA damage and mutations across the nuclear and mitochondrial genome over a lifetime. | no dedicated site yet |
| 2 | Telomere attrition Progressive shortening of the protective chromosome-end caps, limiting replicative capacity. | TeloiX — live |
| 3 | Epigenetic alterations Age-associated changes in DNA methylation, histone modification and chromatin remodeling. | no dedicated site yet |
| 4 | Loss of proteostasis Declining protein quality control, chaperone function and clearance of damaged proteins. | no dedicated site yet |
| 5 | Disabled macroautophagy Reduced autophagic turnover of damaged organelles and aggregates (added as a distinct hallmark in 2023). | no dedicated site yet |
| 6 | Deregulated nutrient-sensing Dysregulation of the insulin/IGF-1, mTOR, AMPK and sirtuin nutrient-sensing network. | MtoriX — live |
| 7 | Mitochondrial dysfunction Declining mitochondrial efficiency, altered dynamics and increased reactive-oxygen-species leakage. | MitoiX — live |
| 8 | Cellular senescence Accumulation of growth-arrested cells with a pro-inflammatory secretory phenotype (SASP). | SenesiQ — live |
| 9 | Stem cell exhaustion Decline in the regenerative capacity of tissue-resident stem-cell pools. | no dedicated site yet |
| 10 | Altered intercellular communication Disrupted endocrine, neuronal and immune signaling between cells and tissues. | no dedicated site yet |
| 11 | Chronic inflammation Persistent, low-grade sterile inflammation ('inflammaging') that rises with age. | no dedicated site yet |
| 12 | Dysbiosis Age-associated shifts in the composition and function of the gut and other microbiota. | no dedicated site yet |
Live mechanism sites
Each card surfaces the site’s own honest strongest-evidence one-liner, verbatim. Every one is amber — real human data, but no healthy-aging lifespan RCT. None is green.
Rapamycin/rapalogs, caloric & protein restriction, metformin: animal-lifespan + human biomarker data; 0 human lifespan RCT.
Senolytics (dasatinib+quercetin, fisetin): small human pilots / senescent-cell biomarker only; UBX0101 phase-2 failed; 0 human lifespan RCT.
Urolithin A / MitoQ / NR / NMN: human functional-biomarker RCTs; CoQ10 (Q-SYMBIO) reduced mortality in heart-failure patients (disease population, NOT healthy aging); 0 healthy-aging lifespan RCT.
TA-65 telomere-length RCTs (telomere length is a contested marker); danazol in rare telomere disease; imetelstat is a telomerase INHIBITOR (cancer drug, opposite direction); 0 human lifespan RCT.
Planned — not yet published
The rest of the network’s owned domains, shown for transparency about the full roadmap. These have no content yet and carry no link — the hub does not point at pages that do not exist. See planned sites.